ea0081ep355 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022
Lempesis Ioannis
, Hoebers Nicole
, Essers Yvonne
, Jocken Johan WE
, Blaak Ellen E
, Manolopoulos Konstantinos N
, Goossens Gijs H
Background: Abdominal obesity is associated with insulin resistance and increased cardiometabolic disease risk, whereas lower-body fat accumulation seems protective against metabolic derangements. Differences in upper-body and lower-body adipose tissue (AT) function seem to underlie these opposing associations. Here, we investigated the inflammatory signature of upper- and lower-body AT in women with normal weight and obesity, as well as in human primary abdominal (ABD) and fe...